Differences in Antibacterial Activity of Benzalkonium Chloride

Benzalkonium solutions obtained from different manufacturers were shown to have different activities. This difference in activity was related to the composition of the benzalkonium chloride. The potential seriousness of this situation is emphasized, and a recommendation is made that the official monographs on benzalkonium chloride be amended appropriately, noting the apparently superior antibacterial activity of the tetradecyl (C14) homolog.