Response of the isolated pancreas to scorpion venom

THE venom of the scorpionTityus trinitatis causes secretion of the secretin stimulated isolated canine pancreas. In the absence of secretin, similar doses of venom evoked no response. The implications of these results are discussed. The results with this isolated model show that the action of the venom is directly on the pancreas. Further, these results provide the opportunity to offer a rationale for the pathogenesis of that form of pancreatitis which occurs following the sting of the scorpion.