Когда начинать антибиотикотерапию у пациентов с сепсисом

According to the recommendations of the Surviving Sepsis Campaign (SSC), antibiotics should be administered within 1 hour after the onset of sepsis, and the centers for Medicare & Medicaid Services prescribe their administration within 3 hours. The objective of this publication is to analyze the literature data on the start time of ABT when a patient with sepsis is admitted to the ICU. Results . Currently, basing on literature analysis, it is impossible to conclude about advantages of administering an antibiotic within an hour after the patient with sepsis is admitted to a medical unit. In the vast majority of cases, an antibiotic should be administered up to three hours of the early IT complex (bundle). The change in the time algorithm for drug administration is due to the heterogeneity of the clinical situation, the lack of the unified "scenario" of interaction between the infection and host, and the need for more detail diagnostics. Conclusion . It is preferable to approach each case individually when deciding about the time to start ABT, considering the history, clinical and laboratory characteristics by the admission to the ICU. However, ABT should be started within 3 hours in any case.