antibodies specific core protein of HIV and uses thereof

An isolated antibody that binds to a core protein HIV-1 and HIV-2, wherein said antibody comprises (a) a heavy chain comprising the amino acid sequence of SEQ ID NO: 54 or SEQ ID NO: 58 and a light chain comprising the amino acid sequence of SEQ ID NO: 55 or SEQ ID NO: 59, or (b) a heavy chain comprising the amino acid sequence of SEQ ID NO: 46 or SEQ ID NO: 50 and a chain light comprising the amino acid sequence of SEQ ID NO: 47 or SEQ ID NO: 51, wherein said antibody immunospecifically binds to p24 with a dissociation constant at equilibrium (KD) of less than 7 pM.