Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis*

ObjectiveTo determine the safety and efficacy of filgrastim (r-metHuG-CSF) in combination with intravenous antibiotics to reduce the rate of mortality in patients with pneumonia and sepsis.DesignThis study was multicenter, double-blind, and randomized.SettingIntensive care unitsPatientsAdult patient