Differential Effects of Kupffer Cell Inactivation on Inflammation and the Liver Sieve Following Caecal-Ligation and Puncture Induced Sepsis in Mice.

ABSTRACTSepsis remains a common clinical problem with significant mortality. Activation of the Kupffer cells during sepsis is associated with systemic inflammatory response and multiple organ failure. Kupffer cell activation also leads to structural changes in the liver sinusoidal endothelial cells