A transgenic mouse model for mammary carcinogenesis

Tumorigenesis is a multistage process involving multiple genetic aberrations. Advances in transgenic and knockout technologies make it possible to genetically engineer mice to mimic the individual steps in this process, in order to better understand events contributing to cancer progression at the molecular level. Specifically, mouse models prone to genetic instability have been generated that may be useful to screen for early molecular events involved in hormonal carcinogenesis.