在有 retinopathy 的类型 2 糖尿病的病人的血浆辅酶 Q10 层次

AIM:To determine the relationship between proliferative diabetic retinopathy(PDRP) and plasma coenzyme Q10 CoQ10 concentration.METHODS:Patients with type 2 diabetes and PDRP were determined to be the case group(n=50).The control group was consist of healthy individuals(n=50).Plasma CoQ10 and malondialdehyde(MDA) levels were measured in both groups.RESULTS:Ubiquinone-10(CoenzymeQ10)levelsinPDRP and control subjects are 3.81±1.19μmol/L and 1.91±0.62μmol/L,respectively.Plasma MDA levels in PDRP and control subjects were 8.16±2μmol/L and 3.44±2.08μmol/L,respectively.Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68,respectively.CONCLUSION:The ratio of ubiquinol-10/ubiquinone10 is found lower in patients with PDRP.High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.