Long non-coding RNA n326322 promotes the proliferation and invasion in nasopharyngeal carcinoma

// Mingyu Du 1, 4, * , Teng Huang 2, * , Jing Wu 4 , Jia-Jia Gu 4 , Nan Zhang 4 , Kai Ding 1 , Lu-Xi Qian 3 , Zhi-Wei Lu 3 , Wen-Jun Zhang 3 , Xiao-Kang Tian 1 , Xia He 1, 4 and Li Yin 4 1 Xuzhou Medical University, Xuzhou, Jiangsu, China 2 Department of Radiation Oncology, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu, China 3 The Fourth Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China 4 Jiangsu Cancer Hospital and Jiangsu Institue of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China * These authors contributed equally to this work Correspondence to: Xia He, email: hexiabm@163.com Li Yin, email: yinli_2012@126.com Keywords: nasopharyngeal carcinoma; lncRNA-n326322; invasion Received: May 01, 2017      Accepted: November 05, 2017      Published: December 01, 2017 ABSTRACT Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC.