11q23 abnormalities in children with acute nonlymphocytic leukemia (M4–M5): Association with previous chemotherapy

Abstract Cytogenetic studies of 12 patients aged less than 14 years with acute nonlymphoblastic leukemia (ANLL) (M4–M5) showed structural abnormalities on chromosome 11 at band q23–q24 in five cases (41.8%). Four of these 12 patients had ANLL (M4–M5) after treatment with cytostatics for non-Hodgkin lymphoma in one case and for an acute lymphoblastic leukemia (ALL) in the other three. Three of these four cases had 11q23 abnormalities [one 46,XY,t(11;17)(q23;25); another 47,XY,+8,−15,del(11)(q23),+der(15)t(15;?)(p11;?); the third 47,XX,+8,t(3;17) (p11;q25),t(4;11)(q21;q23)] and one had a normal karyotype on being diagnosed ANLL (M4–M5). The notable increase of ANLL (M4–M5) in our patients who had received cytostatics as treatment for a previous neoplasia makes evaluation of our results timely in comparison with those of other groups who use these therapeutic protocols.