Idelalisib amorphous substance and preparation method thereof

2015 
The invention relates to an idelalisib amorphous substance and a preparation method thereof. According to the invention, Cu-Kalpha radiation is used, no sharp diffraction peak in a spectrum is diffracted by X-ray powder expressed by degree 2 theta, wherein X-ray powder diffraction is shown in a graph 1. The invention also provides a preparation method of the idelalisib amorphous substance. The idelalisib amorphous substance increase the dissolvability of idelalisib and is in favor of increasing the biological utilization degree of a medicinal preparation, compared with current crystal form idelalisib, solubility is obviously increased, the idelalisib amorphous substance is in favor of absorbing the medicines by the body, so that medicine can better perform clinical disease treatment effect. Under the condition of accelerated testing on the idelalisib amorphous substance, good physical stability and chemical stability can be kept. The preparation method of the idelalisib amorphous substance has the advantages of simple operation and easy realization.
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