Optical studies of acefylline piperazine, chlorpheniramine maleate, thiamine hydrochloride in aqueous, aqueous methanol and aqueous ethylene glycol systems

Abstract Refractive index, FTIR and Uv–vis absorption study of acefylline piperazine, chlorpheniramine maleate, thiamine hydrochloride was done to investigate the solute-solvent interactions. The interaction of drugs (AP, CPM, TAD) studied in aqueous, aqueous methanol and aqueous ethylene glycol systems at 303 K. Specific refraction, Molar refraction and polarizability of drugs in aqueous and aqueous alcoholic systems was calculated by using Lorentz-Lorentz equation. FTIR study of drugs in aqueous and aqueous alcoholic systems was undertaken to analyze the compatibility of drugs in studied systems. The UV–vis absorption study has also been done to interpret the interaction patterns occurring in drugs and solvent systems.