NEOPLASIA PSEUDOPAPILAR SÓLIDA DEL PÁNCREAS .

Resumen La neoplasia pseudopapilar solida del pancreas (NPSP) es un tumor poco frecuente que afecta principalmente a pacientes jovenes. Recientemente se han publicado casos aislados o series de casos, de acuerdo a los avances en el conocimiento y la precision de las tecnicas que permiten su diagnostico. Presentamos un caso de NPSP manejado en el Hospital del Nino, comparando y complementando nuestros hallazgos con los encontrados en la literatura cientifica. Se trata de una paciente femenina de 14 anos, que acudio por palparse una masa en el hemiabdomen derecho, sin otro signo o sintoma, con laboratorios dentro de limites normales. Los estudios de imagen describian la masa y senalaron la NPSP dentro del diagnostico diferencial. Se realizo una cirugia de Whipple, con evolucion post-operatoria inmediata satisfactoria. El diagnostico histopatologico de NPSP fue confirmado mediante pruebas de inmunohistoquimica. La NPSP es un tumor maligno de bajo grado, con altos porcentajes de curacion, que posee caracteristicas singulares que nos permiten sospecharlo y diagnosticarlo si conocemos sus particularidades clinico-patologicas. Un pequeno porcentaje de pacientes presenta tumores clinicamente agresivos, pero aun no existe completa certeza de los factores predisponentes de este comportamiento. Por eso, es importante seguir la evolucion de estos pacientes, indagar por posibles factores de mal pronostico e investigar mas profundamente su patogenesis, aun no completamente dilucidada. Colaboracion de la Academia Panamena de Medicina y Cirugia e Infomedic International S,A. 2006-2013. Derechos reservados. www.revistasmedicas.org Pseudopapillary solid neoplasm of the pancreas. Summary Solid pseudo papillary neoplasia of the pancreas (NPSP) it a rare tumor that mainly affects a Young Patients.  Recently were published isolated cases or series of cases, according Diagnostic advances in knowledge and the accuracy of the techniques that allow them. We present a case of NPSP handled in the Children's Hospital, comparing and complementing our findings with those found in the literature. It Is A female patient aged 14, he came to be felt A mass in the abdomen right direction, without other signs or symptoms, labs within limits Normal. Imaging studies describing the mass and noted the NPSP in the differential diagnosis. Whipple surgery satisfactory immediate post-operative was carried out with development. NPSP histopathological diagnosis was confirmed by immunohistochemistry. The UN tumor is malignant NPSP low-grade, high cure rates, which has unique characteristics that allow us to suspect and diagnose if you know their clinic pathologic characteristics. A small percentage of patients have clinically aggressive tumors, but there are not yet completely certain predisposing factors of this behavior. Therefore, it is important to monitor these patients, investigate for possible factors of poor prognosis and further investigate the pathogenesis, although not elucidated completely. Palabras claves : pancreas, neoplasia pseudopapilar  solida del pancreas, B-catenina, e-cadhenina, pronostico. Key Word : pancreas, pancreatic neoplasia pseudo papillary solid, B-catenin,  e-cadhenina predicted.