Darstellung peroraler Retardarzneiformen auf der Basis von biologisch abbaubaren Polymeren. III: Darstellung von Matrixtabletten auf der Basis von Poly-3-hydroxybuttersäure

It is reported on the preparation and investigation of matrix tablets on the basis of polyactic acid. Caffeine and phenazone served as model drugs. The release values obtained were analyzed by the equations of Noyes-Whitney and of Higuchi. It was demonstrated, that the solubility and the grain size of the drugs, their content in the tablets and an addition of Heweten ® 12 have an influence of the release of the drugs