Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics

Abstract The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F 14 ) formulation showed favorable in vitro release of PC (65%) in 12 h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant ( p 50  = 179.12 μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC 50 value = 856.58 μg/mL) and 93.68% inhibition (IC 50 value = 396.35 μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24 h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics.