Patogenia de las espondiloartropatías seronegativas

Se estudio la funcion que desempena el antigeno leucocitario humano (HLA-B27) en la patogenesis de las espondiloartropatias seronegativas. Se describio detalladamente la zona de union de peptidos de la molecula conocida como «bolson 45». Como hipotesis actuales en el surgimiento de la enfermedad se discutieron la mimica molecular entre bacterias artritogenicas y HLA-B27, la positividad del HLA-B27 y la persistencia de las infecciones enterobacteriales, HLA-B27 factores modificantes y el modelo del peptido artritogenico. Se explico la funcion de la celula T CDB+ en el desencadenamiento de la enfermedad y su control por los linfocitos T CD4+.(AU) The function of HLA-B27 in the pathogenesis of seronegative spondyloarthropathies was studied. The zone of union of the peptides of the molecule known as «big pocket 45» was described in detail. The molecular mimicry between arthritogenic bacteria and HLA-B27, the positivity of HLA-B27 and the persistance of enterobacterial infections, the HLA-B27 modifying factors, and the model of arthritogenic peptide were discussed as present hypotheses connected with the appearance of the disease. The function of the CDB-positive T-cell in the outbreak of the disease, as well as its control by the CD4-positive T-lymphocytes was explained.(AU)