Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines
2015
Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
97
References
45
Citations
NaN
KQI