Studies on Peptides. LXXVIII. Synthesis of the Nonacosapeptide corresponding to the Entire Amino Acid Sequence of Avian Glucagon (Duck)

The nonacosapeptide corresponding to the entire amino acid sequence of duck glucagon was synthesized using methanesulphonic acid as a deprotecting reagent at the final step of the synthesis. Synthetic duck glucagon was obtained in a crystalline form and exhibited the biological activity equivalent to that of porcine glucagon. However, the immunological property of synthetic duck glucagon was found to differ from the mammalian origin.