Impact of red blood cell transfusion (RBCT) on outcome among septic patients admitted into intensive care unit (ICU), a systematic review and meta-analysis

RBCT is still a subject of debate with 2 main questions: what is the optimal threshold? and does transfusion impact the outcome?. Concerning septic patients, a threshold of 10 g/dL was for many years the objective during the first hours of septic shock and since the last surviving sepsis campaign, a threshold of 7 g/dL for stabilized septic patients is proposed. Nevertheless, the evidence base dealing with septic patients remains poor and cohort studies bring divergent results.