An international study on the use of peroral endoscopic myotomy in the management of Zenker’s diverticulum

Abstract Background and Aims The novel use of peroral endoscopic myotomy (POEM) in the treatment of Zenker's diverticulum (ZD) was recently described in case reports. The aim of this study is to report a multicenter experience with the POEM technique in the management of ZD. Patients and Methods This is a multicenter international retrospective study involving 10 centers. Z-POEM was performed using principles of submucosal endoscopy. Results A total of 75 patients (73.3±1.2, years, female n=33) were included with a mean Charleson Comorbidity Index of 4±0.2). The mean size of ZD was 31.3±1.6 mm (10-89 mm). The overall technical success rate was 97.3% (73/75). There were 2 technical failures due to inability to locate the septum and failed tunnel creation. AEs occurred in 6.7% (5/75): 1 bleed (mild) conservatively managed and 4 perforations (1 severe, 3 moderate). The mean procedure time was 52.4±2.9 min and mean length of hospital stay was 1.8±0.2 days. Clinical success was achieved in 92% (69/75) with a decrease in mean dysphagia score from 1.96 to 0.25 (p Conclusion Endoscopic management of ZD using the POEM technique is a novel and feasible with promising efficacy and safety results. Long-term follow-up is needed to ensure durability of response. In addition, comparative studies with other treatment modalities are warranted.