PHARMACOEPIDEMIOLOGY OF ARTERIAL HYPERTENSION IN IRKUTSK REGION

Summary. 0 e awareness (78.2%) and treatment (71.3%) of hypertension in the rural and farthest areas of Irkutsk Region of Russia were relatively high, but hypertension control (3.8%) was very low because of antihypertensive therapy shortcomings. 0 e shortcomings included the unreasonably frequent usage of single-drug therapy, rare usage of durable action antihypertensive drugs and rare usage of rational combinations of antihypertensive drugs recommended by European Society of Cardiologists. Key words: hypertension, treatment, farmacoepidemiology.œ€ƒŒ€…S•–“S# ‡…‘Œ€ƒŒ“—…# (œ4) 5…€ˆ†ˆ €S„‘€ˆ-„ƒ€S“Œ““S ‹ ‘…€Œ … ‹Ž„ˆ†S ‹Œ€ˆ#ƒ“ˆ„ƒ–, $ƒˆ ŒŒ €S„‘€ˆ-„ƒ€S“Œ““ˆ„ƒ– ‹ ‰S•–“Œ†5Œ‘ "‚‰Œƒ ‚‹Œ•…$…‹Sƒ–„# [12]. 6ˆ•Œ—“…, !S€S†ƒŒ€…—‚&'…Œ„# ‘ˆ‹Ž5Œ““Ž‘ S€ƒŒ€…S•–-“Ž‘ ‰S‹•Œ“…Œ‘ (œ9), —S“…‘S&ƒ ‘Œ€‹ˆŒ ‘Œ„ƒˆ ‹ „ƒ€‚†ƒ‚-€Œ —S"ˆ•Œ‹SŒ‘ˆ„ƒ… ‹—€ˆ„•ˆ‡ˆ “S„Œ•Œ“…# "ˆ•Œ—“#‘… „…-„ƒŒ‘Ž †€ˆ‹ˆˆ"€S'Œ“…# ‹ ;ˆ„„…†„†ˆ† ˜Œ‰Œ€S’…… (;˜), „ˆ„ƒS‹•## 7801,4 „•‚$S# “S 100 ƒŽ„. ‹—€ˆ„•ˆ‡ˆ “S„Œ•Œ“…# [4]. ”“ˆ‡ˆ$…„•Œ““ŽŒ …„„•Œ‰ˆ‹S“…# „‹…‰ŒƒŒ•–„ƒ‹‚&ƒ ˆ ‹Ž„ˆ†ˆ‘ —“S$Œ“…… œ4 †S† ’S†ƒˆ€S €…„†S „Œ€‰Œ$“ˆ-„ˆ„‚‰…„ƒŽ! —S"ˆ•Œ‹S“…† (››>), ‡•S‹“Ž‘ ˆ"€S—ˆ‘, …5Œ-‘…$Œ„†ˆ† "ˆ•Œ—“… „Œ€‰’S (•6›) … …“„‚•–ƒS. *‰“S†ˆ … ‰€‚‡…Œ —S"ˆ•Œ‹S“…#, ‹†•&$S# ‘ˆ$Œ$“‚& … „Œ€‰Œ$“‚& “Œ-‰ˆ„ƒSƒˆ$“ˆ„ƒ–, ƒŒ„“ˆ „‹#—S“Ž „ “Œ‰ˆ„ƒSƒˆ$“Ž‘ †ˆ“ƒ€ˆ-•Œ‘ œ9 …•… “Œ•Œ$Œ““ˆ† œ4 [12]. “ ‘ˆ„•Œ‰“…Œ ‡ˆ‰Ž "Ž•… ˆ‘‚"•…†ˆ‹S“Ž €Œ†ˆ‘Œ“-‰S’…… œ‘Œ€…†S“„†ˆ‡ˆ (2003), ;ˆ„„…†„†ˆ‡ˆ (2004) … ?‹€ˆ‘Œ†„†ˆ‡ˆ (2007) ˆ"'Œ„ƒ‹ †S€‰…ˆ•ˆ‡ˆ‹ ‘ˆ ‰…S-‡“ˆ„ƒ…†Œ, ‘€ˆ’…•S†ƒ…†Œ … •Œ$Œ“…& œ4, ˆ„“ˆ‹S““ŽŒ “S €Œ—‚•–ƒSƒS! €S“‰ˆ‘…—…€‚Œ‘Ž! †ˆ“ƒ€ˆ•…€‚Œ‘Ž! … ‘€ˆ„‘Œ†ƒ…‹“Ž! …„„•Œ‰ˆ‹S“…† [3; 9; 11]. “ /ƒ…! €Œ†ˆ-‘Œ“‰S’…#! ˆ‘€Œ‰Œ•Œ“Ž ‘ˆ†S—S“…# … ‘€ˆƒ…‹ˆ‘ˆ†S—S“…# ‰•# “S—“S$Œ“…# S“ƒ…‡…‘Œ€ƒŒ“—…‹“Ž! ‘€Œ‘S€Sƒˆ‹ (œ™), ‘€Œ‰„ƒS‹•Œ“Ž /’’Œ†ƒ…‹“ŽŒ „ƒ€SƒŒ‡…… ‘Œ‰…†S‘Œ“ƒˆ—-“ˆ‡ˆ •Œ$Œ“…# œ4. 9•# ƒŒ€S‘…… œ4 €Œ†ˆ‘Œ“‰ˆ‹S“Ž „Œ‘– †•S„„ˆ‹ œ™: ‰…‚€Œƒ…†…, β-S‰€Œ“ˆ"•ˆ†Sƒˆ€Ž (6œ6), S“ƒS‡ˆ“…„ƒŽ †S•–’…# (œs), …“‡…"…ƒˆ€Ž S“‡…ˆƒŒ“—…“-‘€Œ‹€S'S&'Œ‡ˆ ’Œ€‘Œ“ƒS (•œ™˜), "•ˆ†Sƒˆ€Ž €Œ’Œ‘-ƒˆ€ˆ‹ S“‡…ˆƒŒ“—…“S (6;œ), S‡ˆ“…„ƒŽ …‘…‰S—ˆ•…“ˆ‹Ž! €Œ’Œ‘ƒˆ€ˆ‹ (œ•;) … α-S‰€Œ“ˆ"•ˆ†Sƒˆ€Ž [3].sS† ‘ˆ†S—S•… €Œ—‚•–ƒSƒŽ ‘Œ€‹ˆ‡ˆ ;ˆ„„…†„†ˆ‡ˆ …„-„•Œ‰ˆ‹S“…# *‘ƒ…‘S•–“ˆ‡ˆ ›“…+Œ“…# œ9 (;*›œ), ‘€S‹…•–“ˆŒ ‹Ž‘ˆ•“Œ“…Œ €Œ†ˆ‘Œ“‰S’…† ‘ˆ—‹ˆ•#Œƒ ‰ˆ-"…ƒ–„# „ƒS"…•–“ˆ‡ˆ „“…+Œ“…# œ9 ‰ˆ ’Œ•Œ‹ˆ‡ˆ ‚€ˆ‹“# (œ9 S‘S‰“ˆ† ?‹€ˆ‘Ž — ‹ „€Œ‰“Œ‘ 8%, ‹ „ƒ€S“S! ›Œ‹Œ€“ˆ† œ‘Œ€…†… — 23% [13], ‹ ;˜ — 20,5% ‚ ‘‚+$…“ … 22,5% ‚ +Œ“'…“ [7]. •‘Œ&ƒ„# ˆ„“ˆ‹S“…# ‘€Œ‰‘ˆ•S‡Sƒ–, $ƒˆ ‹ ›…"…€„†ˆ‘ €Œ‡…ˆ“Œ, ˆ„ˆ"Œ““ˆ ‹ „Œ•–„†…! … ˆƒ‰S•Œ““Ž! €S†ˆ“S!, ‚€ˆ‹“… ˆ„‹Œ‰ˆ‘•Œ““ˆ„ƒ…, •Œ$Œ“…# … †ˆ“ƒ€ˆ•# œ4 ‘ˆ‡‚ƒ "Žƒ– “…+Œ, $Œ‘ ‹ „€Œ‰“Œ‘ ‘ˆ ;˜, ‚$…ƒŽ‹S# "ˆ•–5‚& ‘€ˆƒ#+Œ““ˆ„ƒ– ƒŒ€€…ƒˆ€……, ‘S•‚& ‘•ˆƒ“ˆ„ƒ– “S„Œ•Œ-“…#, “Œ‰ˆ„ƒSƒˆ† ‹€S$Œ"“Ž! †S‰€ˆ‹, ‘S•‚& ‰ˆ„ƒ‚‘“ˆ„ƒ– ‘Œ‰…’…“„†ˆ† ‘ˆ‘ˆ'… … ƒ#+Œ•ŽŒ †•…‘Sƒ…$Œ„†…Œ ‚„•ˆ-‹…#.KŒ•–& “S„ƒˆ#'Œ‡ˆ …„„•Œ‰ˆ‹S“…# #‹…•ˆ„– ˆ‘€Œ‰Œ•Œ-“…Œ ‚€ˆ‹“Œ† ˆ„‹Œ‰ˆ‘•Œ““ˆ„ƒ…, •Œ$Œ“…# … †ˆ“ƒ€ˆ•# œ4 … S“S•…— S“ƒ…‡…‘Œ€ƒŒ“—…‹“ˆ† ’S€‘S†ˆƒŒ€S‘…… ‹ „Œ•–-„†…! … ˆƒ‰S•Œ““Ž! €S†ˆ“S! •€†‚ƒ„†ˆ† ˆ"•S„ƒ….