Synthesis of Pelorol and analogues: activators of the Inositol 5-Phosphatase SHIP

Lu Yang,David E. Williams,A Mui,C. Ong,Gerald Krystal,R.W.M. van Soest,Raymond J. Andersen

Synthesis of Pelorol and analogues: activators of the Inositol 5-Phosphatase SHIP

2005

Lu Yang
David E. Williams
A Mui
C. Ong
Gerald Krystal
R.W.M. van Soest
Raymond J. Andersen

A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).

Keywords:

Sclareolide
Activator (genetics)
Inositol
Organic chemistry
Phosphatase
Biochemistry
Chemistry
inositol 5 phosphatase
Phosphoric monoester hydrolases
Inositol Polyphosphate 5-Phosphatases
Stereoisomerism
Stereochemistry
In vitro

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