Segmentation of the Common Carotid Intima-Media Complex in Ultrasound Images Using 2-D Continuous Max-Flow and Stacked Sparse Auto-encoder.

Abstract The intima-media thickness (IMT) of a common carotid artery in an ultrasound image is considered an important indicator of the onset of atherosclerosis. However, it is challenging to segment the intima-media complex (IMC) directly in ultrasound images. This study proposes a fully automatic method to segment the IMC on longitudinal B-mode ultrasound images. Our method consists of two stages: (i) extraction of the region of interest with a continuous max-flow algorithm and region-of-interest reconstruction using a stacked sparse auto-encoder model, and (ii) IMC segmentation using a trained random forest classifier. The proposed method has been tested on three databases from three different imaging centres, comprising a total of 228 ultrasound images of the common carotid artery. On the three databases, our method yields mean absolute errors of 0.028 ± 0.016 mm, 0.579 ± 0.288 pixel and 0.582 ± 0.341 pixel; polyline distance (PD) measures of 0.026 ± 0.017 mm, 0.657 ± 0.275 pixel and 0.731 ± 0:282 pixel; Hausdorff distance measures of 0.249 ± 0.101 mm, 4.760 ± 1.085 pixels and 5.825 ± 2.059 pixels; and correlation coefficients of 95.19%, 93.79%, and 98.96%, respectively. These results indicate that the proposed method performs well in segmentation of the IMC and measurement of the IMT.