Expression of alpha tubulin during the dimorphic transition of Paracoccidioides brasiliensis

In this study we analyzed the expression of α-tubulin during the dimorphic transition of the human-pathogenic fungus Paracoccidioides brasiliensis. The α-tubulin from P. brasiliensis was recognized by a commercially available anti-tubulin antibody and was developmentally regulated during the dimorphic form transition. We detected at least two α-tubulin isoforms in the mycelial state and only one isoform in the yeast forms. This finding suggests specific roles for the α-tubulin isoforms in P. brasiliensis's yeast and mycelial forms.