Contact lens-related deep stromal vascularization

Abstract Deep stromal neovascularization (DNV) is a very rare complication of contact lens (CL) wear. The aim of this study was to describe the clinical features and management of CL-related DNV in a series of patients. We retrospectively studied nine patients who presented with CL-related DNV over a 16-year period in a single hospital-based specialty CL practice. The clinical features, progression, and management of DNV in this series are discussed. Seven of nine patients were found to have keratoconus as a primary diagnosis. DNV remained stable or regressed in six patients following improvement in CL design and management. One patient required corneal transplantation, and two failed to return for sufficient follow-up. Improvement in CL design and material to optimize mechanical fit and enhance corneal oxygenation may stabilize DNV associated with CL wear.