anti-TNF antibodies and methods of use

An antibody that can bind TNF alpha, wherein the antibody comprises: (a) a polypeptide comprising a polypeptide having the sequence shown in SEQ ID NO: 2; and (b) a polypeptide comprising a polypeptide having the sequence shown in SEQ ID NO: 380, wherein said antibody binds to TNF alpha higher than infliximab affinity as determined using a Biacore assay and in the the VH region infliximab has the sequence shown in SEQ ID NO: 1 and the VL of infliximab has the sequence shown in SEQ ID NO: 379.