Modulators of GPR40 bifenilfenoxi, thiophenyl and substituted acids aminofenilpropanoico

Compound having the formula I: ** ** Formula or a salt, solvate or stereoisomer pharmaceutically acceptable thereof; or taut6mero or a salt, solvate or stereoisomer 5 pharmaceutically acceptable thereof; or a mixture thereof, in Quex is 0; W, Y and Z are all CH; R1 is selected from H, (C1-C6), alkenyl (C2-C6) -alkenyl or (C2-C6); Rla is H; R2 is selected from F or alkoxy (C3-C6); R3 is alkoxyl (Ci-C2); R4, R5 and R6 are independently selected from H and alkyl (C1-C4) -alkyl and at least two of R4, R5 and R6son (C1-C4), and two of R4, R5 and R6 may join together to form a 3- to 7-membered; R7 and R8 are H; R9 and R1 ° is independently selected from H and alkyl (Ci-C4); each R11 is independently selected from F, Cl, (C1-C4) alkyl or (C1-C4) and m is 0; ycada R12 is independently selected from F, Cl, (C1-C4) alkyl or (C1-C4) and n is 0.