Abstract 17469: Prognostic Utility of the Hemoglobin/Hematocrit Equation for Estimating Plasma Volume Changes During Hospitalization for Acute Decompensated Heart Failure

Background: Plasma volume (PV) expansion underlies systemic congestion in acute decompensated heart failure (ADHF) but changes in PV during hospitalisations are poorly estimated by clinical examination. Whilst radioisotope assays optimally quantify PV status, numerous validated formulae also exist for its estimation. The hemoglobin (Hb) / hematocrit (Hct) equation is an index of temporal changes in PV (%[[Unable to Display Character: ∆]]PV) that is predicated on the disproportionate alterations in Hb and Hct during PV fluctuations. We tested its prognostic utility in patients admitted with ADHF. Methods: We analysed the relation between mortality and %[[Unable to Display Character: ∆]]PV from admission to discharge in 337 ADHF patients (mean [±SD] age 70±13yr, 67% male, LVEF 29±8%, 61% LVEF<45%). %[[Unable to Display Character: ∆]]PV was derived using the following equation: (([(HbW/Hbx) x ((100-Hcty) / (100-Hctz))] -1) x 100%). Results: Over a median (±IQR) hospital stay of 10±13 days, ...