Prevalence of Monoclonal Gammopathy in Patients With Primary Hyperparathyroidism

Results: Monoclonal immunoglobulin was detected in 10 (10%) of 101 patients with PHPT (including 2 with multiple myeloma) compared with 2 (2%) of 127 patients who underwent other surgery (P=.005) and 3 (3%) of 101 patients with benign thyroid diseases (P=.04). Conclusions: The prevalence of monoclonal gammopathies is high in patients with PHPT. At minimum, sensitive serum protein electrophoresis should be performed routinely in all patients with PHPT. Conversely, in patients with monoclonal gammopathy who have hypercalcemia but no other symptoms of progressive disease, clinicians must seek PHPT. Arch Intern Med. 2002;162:464-467