Effect of Microembolization on Left Ventricular Systolic Wall Motion and Dyssynchrony Using Dipyridamole Stress Two-dimensional Speckle Tracking Imaging: An Experimental Study

Objectives To investigate whether subtle myocardial injury caused by coronary microembolization (CME) can induce left ventricular contractile dysfunction or dyssynchrony on swine models. Materials and methods CME swine models were constructed by the injection of 150,000 microspheres into the left coronary artery compared with the control group. The peak systolic values of longitudinal strain (LS), radial strain (RS), and circumferential strain (CS) by two-dimensional speckle tracking imaging (2D-STI) were measured under resting stage and dipyridamole stress prior to, 6 hours after, and 1 week after CME. The mean standard deviation of 12 segmental time-to-peak longitudinal strain (Tls-12SD), radial strain (Trs-12SD), and circumferential strain (Tcs-12SD) of the left ventricle were calculated as the dyssynchrony index. Results Postmortem analysis demonstrated 29.76% of the left ventricular segments manifested myocardial necrosis in MCE group compared with the control group (0%, p p  > 0.05). In the CME group, compared with the baseline, LS on the basal anterior wall deteriorated from −9.72 ± 4.96 % to −6.35 ± 3.75 % ( p p p p p Conclusion Subtle cardiac systolic dysfunction as well as dyssynchrony caused by CME can be detected using dipyridamole stress 2D-STI sensitively. Moreover, left ventricular dyssynchrony could be affected even by slight myocardial injury.