The Experimental Study of Collagen Membrane Combined with Bio-Oss on the Effect of Bone Formation

Objective To evaluate the effect of bone formation of Bio-Oss used alone or in combined with bioresorbable collagen membrane.Methods 1 cm x 1 cm areas were formed on bilateral of mandibles of three dogs.Left side was experimental group:Bio-Oss + collagen membrane + titanium screws fixing.Right side was set as control:used Bio-Oss only.The macroscopic,histological and scanning electron microscope observations were performed at twelve weeks after surgery.Results Two groups all have new bone formed.In experimental group:mature osteocytes and Haversian lamellar could be seen,plenty of bone trabeculae arranged orderly.In control group:massive osteoblasts and bone trabeculae irregular arranged were found,which was lower in bone mature than experimental group.Conclusion Bone formation effectiveness of Bio-Oss combining with collagen membrane fixing is better than that of Bio-Oss only.