Studies on nitrosamine metabolism. III. Comparison of the subcellular distribution of radioactivity in tissues of RFM and BALB/c mice following administration of [14C]diethylnitrosamine.

The tissue distribution of radioactivity in male RFM and BALB/c mice was investigated following a single dose of (/sup 14/C)-labeled diethylnitrosamine (DEN). The radiolabel was associated with all the subcellular fractions, and the majority of the radioactivity was located in the cytosol fraction. The majority of the radiolabel was usually eliminated from the fractions within 16-24 hrs after (/sup 14/C)DEN administration.