Synthesis and antiviral activity of functionally substituted indole-3-acetic acids

Methods for the synthesis of dibromo-substituted derivatives of indomethacin and related N-alkylated indole-3-acetic acid derivatives have been developed. Pathways for the introduction of various substituents, in particular nitrogen-containing groups, into the structure of auxins have been studied. The antiviral activity of some brominated functionally substituted compounds with respect to A/Aichi/2/69 influenza virus in MDCK cell culture and an influenza pneumonia model in mice has been evaluated.