Abstract 593: ApoB-Lipoprotein Association With Insulin Resistance and Hyperinsulinemia: is Activation of the IL-1ß System Involved?

INTRODUCTION: Elevated apoB-lipoproteins is reported to predict type 2 diabetes (T2D) development in postmenopausal women. Low insulin sensitivity (IS) and compensatory hyperinsulinemia is believed to lead to β-cell exhaustion and increase T2D risk. Also, activation of the interleukin-1β (IL-1β) system, a novel inflammatory pathway, is known to predict the development of T2D. We thus aimed to investigate whether plasma apoB associates with low IS and hyperinsulinemia and whether this is via an activation of the IL-1β system. METHODOLOGY: 47 non-diabetic overweight and obese postmenopausal women and 28 men, aged 45 to 74 years old, underwent a modified Botnia clamp, in which 1st and 2nd phase insulin secretion were measured during a 1 hour intravenous glucose tolerance test (IVGTT). Following that, a 3 hour hyperinsulinemic-euglycemic clamp (HEIC, insulin infusion rate of 75 mU/m2/min) was conducted to measure IS during the last 30 minutes (steady state). IS was expressed as steady state glucose infusion r...