Carcinosarcoma of the uterine cervix with a clear cell adenocarcinoma component

Carcinosarcoma of the uterine cervix is a rare neoplasm with only 40 reported cases, so there is no international consensus concerning its clinical characteristics, treatment, and prognosis. For the first time, we report a cervical carcinosarcoma with a clear cell adenocarcinoma component treated successfully by following guidelines for treating cervical carcinoma. The patient, a 47-year-old woman presenting with watery vaginal discharge, was diagnosed with uterine cervical carcinosarcoma. She underwent modified radical hysterectomy or type II hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. The post-operative histopathologic stage was pT2b, pN0, M0 and pathological examination of the surgical specimens demonstrated carcinosarcoma with a clear cell adenocarcinoma component. She had no history of exposure to diethylstilbesterol in utero. We also performed a human papillomavirus detection and genotyping investigation and didn’t find human papillomavirus in either the carcinomatous or the sarcomatous lesion. Postoperative concurrent cisplatin chemotherapy and whole pelvic irradiation plus brachytherapy were performed. The patient remained free of disease 5 years after her last treatment. Although the rarity of this tumor precludes the determination of an optimal therapy in the setting of a clinical trial, treatment according to the guidelines for high risk cervical carcinoma is likely a reasonable alternative.