QUANTITATIVE EVALUATION OF PLASMA PROTEINS, LIPID PROFILE, LIVER AND KIDNEY FUNCTION PARAMETERS AFTER CHRONIC ADMINISTRATION OF “PRADARANTAK LOUHA” TO MALE SPRAGUE –DAWLEY RATS

Background: Pradarantak Louha (PDL), a herbomineral Ayurvedic medicine has been used as a traditional medicine in the treatment of leucorrhoea for many years. Objectives: To evaluate the effect of Pradarantak Louha on major body organs. We assessed the possibility of side-effects after long term administration of Pradarantak Louha. Materials and Methods: To evaluate the effect of PDL, it was administered to the rats at a dose of 400 mg/kg for 54 days. Result: PDL does not change the plasma proteins (Total protein, albumin, and globulin) significantly. The change of bilirubin content was also not significant. In case of kidney function parameters, statistical significant increase was noted in both the creatinine content (p value: 0.015) and urea content (p value: 0.012). To assess the effect of PDL on cardiovascular health, lipid profile of rats were assayed and no significant changes were found. Conclusion: The outcome of this study implies that PDL is safe for our body but care should be taken when it is administered for long term and when it is accompanied by any kidney complications.