Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium

Abstract The threshold for ventricular fibrillation induced by a 200 msec train of pulses was measured during a control period and during an intravenous infusion of nitroglycerin in 14 nonischemic open chest dogs. Infusion of nitroglycerin in doses sufficient to reduce mean arterial blood pressure an average of 17 mm Hg was associated with a rise in ventricular fibrillation threshold from a control value of 24 ± 3 (mean ± 1 standard error of the mean) to 41 ± 6 milliamperes ( P P