Synthesis method for 4-methyl-5-(2-ethoxyl)-thiazole

The invention provides a preparation method for 4-methyl-5-(2-ethoxyl)-thiazole. The 4-methyl-5-(2-ethoxyl)-thiazole is synthesized from 2-acetylbutyrolactone serving as a raw material through amination, chloration, condensation and oxidative reaction. The preparation method comprises the following steps of: introducing chlorine into 2-acetylbutyrolactone and hydrolyzing to obtain 3-acetyl chloride propyl alcohol; introducing ammonia gas into carbon bisulfide to obtain ammonium salt; oxidizing a condensation product of 3-acetyl chloride propyl alcohol and the ammonium salt with hydrogen peroxide or oxygen to obtain a product; extracting with dichloromethane; removing the dichloromethane; then performing reduced pressure distillation; and collecting fraction at 120-127 DEG C under the pressure of 395-400 Pa. The synthesis method has the advantages of readily available raw material, low production cost, simple process, mild reaction conditions and yield of reaching up to 82 percent.