677 La microglie sous rétinienne est à l’origine des drusen observés chez les souris invalidées pour le récepteur aux chimiokines CX3CR1

But Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age related macular disease (AMD). Histologically, drusen are believed to be dome-shaped or more confluent lipid accumulations between the retinal pigment epithelium and the choroicapillaries. Objectifs and Methods Recent advances in mouse fundoscopy have revealed the presence of drusen-like structures in chemokine knockout animals in the absence of sizeable dome-shaped material below the RPE. Results We show that aged CX3CR1-/- mice present with drusen-like appearance in funduscopy that is associated with a progressive age-related microglial cell. Discussion As bloated subretinal MCs can also be found in the human disease. Conclusion We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid bloated subretinal MCs rather than sub-RPE deposits.