Perivascular CD73+ cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment

Heather M. Perry,Nicole Görldt,Sun-sang J. Sung,Liping Huang,Kinga P. Rudnicka,Iain M. Encarnacion,Amandeep Bajwa,Shinji Tanaka,Nabin Poudel,Junlan Yao,Diane L. Rosin,Jürgen Schrader,Mark D. Okusa

Perivascular CD73+ cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment

2019

Heather M. Perry
Nicole Görldt
Sun-sang J. Sung
Liping Huang
Kinga P. Rudnicka
Iain M. Encarnacion
Amandeep Bajwa
Shinji Tanaka
Nabin Poudel
Junlan Yao
Diane L. Rosin
Jürgen Schrader
Mark D. Okusa

Progressive tubulointerstitial fibrosis may occur after acute kidney injury due to persistent inflammation. Purinergic signaling by 5'-ectonucleotidase, CD73, an enzyme that converts AMP to adenosi...

Keywords:

Inflammation
Biochemistry
Acute kidney injury
Biology
Adenosine
Pathology
Purinergic signalling
Ectonucleotidase
Fibrosis
Kidney
Pericyte
tubulointerstitial fibrosis

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