Long-term diet-induced, tissue-specific changes in (non)adipose triglyceride stores in obese patients with type 2 diabetes mellitus

A very low calorie diet (VLCD) induces considerable weight loss in patients with type 2 diabetes mellitus, associated with improved insulin sensitivity and decreased triglyceride (TG) stores in (non)adipose tissues. Long-term effects of a VLCD on tissue-specific TG accumulation, including pericardial fat, have not been documented.