Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention A Subgroup Analysis of a Randomized Clinical Trial

Alina Solomon,Heidi Turunen,Tiia Ngandu,Markku Peltonen,Esko Levälahti,Seppo Helisalmi,Riitta Antikainen,Lars Bäckman,Tuomo Hänninen,Antti Jula,Tiina Laatikainen,Jenni Lehtisalo,Jaana Lindström,Teemu Paajanen,Satu Pajala,Anna Stigsdotter-Neely,Timo E. Strandberg,Jaakko Tuomilehto,Hilkka Soininen,Miia Kivipelto

Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention A Subgroup Analysis of a Randomized Clinical Trial

2018

IMPORTANCE: The role of the apolipoprotein E (APOE) epsilon 4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear. OBJECTIVE: To examine whether ...

Keywords:

Randomized controlled trial
Subgroup analysis
Apolipoprotein E
Physical therapy
Cognition
Psychology
cognitive change
lifestyle intervention
Internal medicine
Medicine

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