Cell–Extracellular Matrix Interactions in Repair and Regeneration

Abstract Cell–matrix interactions that occur during wound healing are extraordinarily complex, varying among cell types and changing over time owing to altered expression of matrix receptors and matrix molecules over time as healing proceeds. In this chapter, we summarize critical cell–matrix interactions associated with wound healing, discussing the matrix receptors involved in these interactions and major signaling pathways regulated by these interactions. We then compare cell–matrix interactions in normal adult scarring wound healing with fetal scarless healing. Finally, we discuss implications of cell–matrix interactions for regenerative medicine, focusing on the ways this information is used to promote regenerative wound healing.