Pharmacokinetics and Toxicodynamics of Oxaliplatin in Rats: Application of a Toxicity Factor to Explain Differences in the Nephrotoxicity and Myelosuppression Induced by Oxaliplatin and the Other Platinum Antitumor Derivatives

Purpose We previously reported that the product of the area under the plasma concentration–time curve (AUCp) and a toxicity factor, which in turn was defined as the product of the apparent ratio of tissue to plasma concentration (Kpapp) and the apparent hydrolysis rate constant (khydrolysis), was a determinant of the different degrees of toxicities induced by platinum drugs, cisplatin, carboplatin and nedaplatin. We tested this model with oxaliplatin.