Influence of Dialysis Modalities on Removal Efficiency of Serum AGE-Peptides determined by FIA

Abstract Aim: To compare the removal efficiency for advanced glycosylation end products-peptides (AGE-P) from serum of patients with end stage renal disease (ESRD) by different type of dialysis membrane and modalities. Methods: 78 patients with ESRD were randomly divided into three groups: polysulfon membrane (F6), bichloroacetate cellulose membrane (CA150), hemophane membrane (HE). They were on hemodialysis（HD） with these three different types of low-flux (LF) membranes. Among these people, 66 patients were randomly divided into three groups: HD with LF membranes, HD with High-flux (HF) membranes, HDF. The serum AGE-P concentrations were measured by using flow injection assay (FIA) at the time before and after HD or HDF. Results: In LF-HD, the reduction rate of AGE-P is not significantly different among F6, CA150 and HE. The significant decrease of serum AGE-P was observed after HDF comparing with LF-HD. The significant reduction of serum AGE-P was observed after HDF treatment comparing with LF-HD, but not statistically significant with HF-HD. Conclusions: The serum AGE-P level in patients with ESRD is elevated and can be removed by HD and HDF. HF-HD or HDF was superior to remove the AGE-P in dialysis patients.