Pathogenesis of brain lesions caused by experimental epilepsy: Light- and electron-microscopic changes in the rat cerebral cortex following bicuculline-induced status epilepticus

Status epilepticus with a duration of 1 or 2 h was induced in rats by i. v. injection of the GABA receptor blocking agent, bicuculline. Immediately there-after, or following a 2 h recovery period, the brains were fixed by vascular perfusion and processed for light and electron microscopy to characterize the type and distribution of morphological changes in the hippocampal formation.