К вопросу о роли аденозина в механизмах развития и прогрессирования болезней легких

In the mini-review the data are shown about the participation of extracellular adenosine in the mechanisms of respiratory diseases development. It has been shown an increase in extracellular adenosine concentration in lung tissue biopsy, bronchoalveolar lavage, blood and exhaled breath condensate of patients with chronic lung disease. The effects of extracellular adenosine are very different and depend on its concentration and the type of receptor, with which it interacts. It is shown the different points of view, devoted to discussion of pro –inflammatory and protective effects after adenosine’s binding with A2A and A2B receptors in acute and chronic inflammation. The implementation of pro-inflammatory effect of adenosine is by the induction of cytokine synthesis, modulating the function of cells involved in inflammation. The role of extracellular adenosine in the process of fibrosis of lung tissue is discussed. There are data on the effects of adenosine dualism in acute and chronic hypoxia.