The role of piriform associative connections in odor categorization

Imagine bringing your groceries home and tucking them into the refrigerator. You’ll probably organize the items by categories: lemons and oranges into the fruit drawer, carrots and cauliflower into the vegetable drawer. Categorization is essential, allowing us to interact with the world in the most efficient way possible. If the differences between objects are not relevant to the task at hand, the brain will group objects together based on their shared properties and develop mental representations of the “categories”. Importantly, we are still aware of the distinctions between objects within the same category. Categories of odor (for example, minty or fruity) are represented in a part of the brain called the olfactory (or piriform) cortex, which receives information from odor cues as well as “top-down” information from other areas of the brain. But how do these top-down pathways influence odor categorization? Bao et al. asked how the brain solves the problem of categorizing odors. For the experiments, human volunteers smelled six familiar odors belonging to three different categories while their brain activity was monitored using a magnetic resonance imaging (fMRI) scanner. Then, half of the participants were given a drug called baclofen that prevents top-down inputs, but not odor cues, from reaching the piriform cortex, while the rest received a placebo. After five days of taking the medication, all of the volunteers had another session of fMRI where they had to categorize the same odors as before. The experiments show that when comparing the fMRI scans before and after the drug treatment, the representations of odors belonging to the same category became more distinct in the piriform cortex in the placebo group. Put differently, as the volunteers were repeatedly exposed to odors of well-known categories, they became better at discriminating individual odors within the same category. However, these changes were disrupted in the group of volunteers that took baclofen. Bao et al.’s findings indicate that this “practice makes perfect” approach to recognizing odors relies on top-down inputs into the piriform cortex. In future work it will be important to study the roles of these inputs in learning new categories of odors, and to investigate whether the mechanisms identified here apply to other sensory information and to more abstract knowledge.