Sedative for skin to respond to external stimuli and method used for tranquilizing respond

The invention aims to provide a drug used for tranquilizing the respond of skin for external stimuli, which is realized by promoting components of CD 39 genetic expression in Langerhans cells. More concretely, the invention promotes CD 39 genetic expression based on the discovery of components of carboxymethyl-beta dextran or salt thereof, polyoxyethylene (POE)/ Polyoxypropylene (POP) Random copolymer of dimethyl ether, and rose water.