Влияние фенотипа окислительного метаболизма на выраженность клинической картины и эффективность эрадикации Helicobacter pylori у больных гастроэзофагеальной рефлюксной болезнью

Determination of oxidative metabolic phenotype in patients with gastroesophageal reflux disease allowed analyzing peculiarities of clinical signs of gastroesophageal reflux disease as well as efficiency of Helicobacter pylori eradication in the patients in question. While investigating symptoms of reflux (heartburn) and noncardiac chest pain it was revealed that patients with fast oxidative metabolic phenotype experiencing painful sensations were found rarer compared to the group with very slow metabolizers. Patients with gastroesophageal reflux disease proved to reduce the frequency of Helicobacter pylori eradication in the subgroup of fast and slow metabolizers in comparison with very slow metabolizers.